Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4912204..4912806 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M5T11_RS23795 Protein ID WP_000897305.1
Coordinates 4912495..4912806 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5T11_RS23790 Protein ID WP_000356395.1
Coordinates 4912204..4912494 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS23755 (4907827) 4907827..4908729 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M5T11_RS23760 (4908726) 4908726..4909361 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M5T11_RS23765 (4909358) 4909358..4910287 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
M5T11_RS23770 (4910469) 4910469..4910711 - 243 WP_021523315.1 hypothetical protein -
M5T11_RS23775 (4910930) 4910930..4911148 - 219 WP_001295676.1 CopG family transcriptional regulator -
M5T11_RS23780 (4911567) 4911567..4911845 - 279 WP_001306650.1 hypothetical protein -
M5T11_RS23785 (4911907) 4911907..4912119 - 213 WP_000197769.1 hypothetical protein -
M5T11_RS23790 (4912204) 4912204..4912494 - 291 WP_000356395.1 NadS family protein Antitoxin
M5T11_RS23795 (4912495) 4912495..4912806 - 312 WP_000897305.1 hypothetical protein Toxin
M5T11_RS23800 (4913035) 4913035..4913943 + 909 WP_001306651.1 alpha/beta hydrolase -
M5T11_RS23805 (4914112) 4914112..4915026 - 915 WP_077634137.1 transposase -
M5T11_RS23810 (4915039) 4915039..4915926 - 888 Protein_4654 hypothetical protein -
M5T11_RS23815 (4916342) 4916342..4917283 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5T11_RS23820 (4917328) 4917328..4917765 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T256604 WP_000897305.1 NZ_CP103762:c4912806-4912495 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT256604 WP_000356395.1 NZ_CP103762:c4912494-4912204 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References