256581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 731967..732660 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M5T11_RS03515 Protein ID WP_000415584.1
Coordinates 731967..732263 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5T11_RS03520 Protein ID WP_000650107.1
Coordinates 732265..732660 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS03480 (727055) 727055..727369 - 315 WP_000958598.1 putative quinol monooxygenase -
M5T11_RS03485 (727400) 727400..727981 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M5T11_RS03490 (728300) 728300..728632 + 333 WP_023149630.1 DUF2645 family protein -
M5T11_RS03495 (728678) 728678..730027 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
M5T11_RS03500 (730024) 730024..730683 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M5T11_RS03505 (730835) 730835..731227 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5T11_RS03510 (731280) 731280..731762 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M5T11_RS03515 (731967) 731967..732263 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M5T11_RS03520 (732265) 732265..732660 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5T11_RS03525 (732793) 732793..734400 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M5T11_RS03530 (734538) 734538..736796 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T256581 WP_000415584.1 NZ_CP103762:731967-732263 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT256581 WP_000650107.1 NZ_CP103762:732265-732660 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References