Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 19732..20273 Replicon plasmid pGXY030
Accession NC_016028
Organism Gluconacetobacter medellinensis NBRC 3288

Toxin (Protein)


Gene name yoeB Uniprot ID G2I8S5
Locus tag GLX_RS17865 Protein ID WP_014106724.1
Coordinates 19732..20001 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G2I8S6
Locus tag GLX_RS16250 Protein ID WP_010668421.1
Coordinates 19998..20273 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLX_RS16220 15219..16064 - 846 WP_007396167.1 IS21-like element helper ATPase IstB -
GLX_RS16225 16061..17311 - 1251 WP_007396168.1 IS21 family transposase -
GLX_RS18335 17457..17798 - 342 Protein_21 lactate dehydrogenase -
GLX_RS16235 17838..18932 - 1095 WP_014106722.1 Fic family protein -
GLX_RS16240 19048..19719 - 672 WP_173572193.1 hypothetical protein -
GLX_RS17865 19732..20001 - 270 WP_014106724.1 Txe/YoeB family addiction module toxin Toxin
GLX_RS16250 19998..20273 - 276 WP_010668421.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GLX_RS16255 20499..20636 - 138 WP_014106725.1 hypothetical protein -
GLX_RS16260 20662..21054 - 393 WP_010668423.1 PIN domain nuclease -
GLX_RS16265 21051..21245 - 195 WP_010516209.1 type II toxin-antitoxin system VapB family antitoxin -
GLX_RS16270 21300..24389 - 3090 WP_041247983.1 Ti-type conjugative transfer relaxase TraA -
GLX_RS16275 24486..24845 + 360 WP_014106728.1 conjugal transfer protein TraD -
GLX_RS16280 24910..25176 + 267 WP_041247990.1 conjugal transfer protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..28572 28572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10563.91 Da        Isoelectric Point: 7.3582

>T25656 WP_014106724.1 NC_016028:c20001-19732 [Komagataeibacter medellinensis NBRC 3288]
VKVIFHEDGWEDYLSWFQSDNAVLEKINALIEDVRRHPFQGIGKPEPLKGQLSGWWSRRITGEHRLVYRVQGRAGEDQRI
EIAQCRFHY

Download         Length: 270 bp

>T25656 NC_016028:c20001-19732 [Komagataeibacter medellinensis NBRC 3288]
GTGAAAGTCATTTTTCATGAAGATGGCTGGGAGGATTATCTTTCGTGGTTTCAGTCAGACAATGCGGTTCTTGAGAAGAT
CAATGCCCTGATCGAGGATGTGCGTCGGCATCCGTTTCAGGGGATAGGGAAGCCGGAACCCCTGAAGGGGCAGCTTTCTG
GGTGGTGGTCCCGACGGATTACGGGAGAACATCGTCTGGTCTACCGGGTTCAGGGGCGCGCGGGAGAGGATCAGCGAATC
GAGATTGCCCAGTGCCGGTTTCATTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10206.37 Da        Isoelectric Point: 5.1070

>AT25656 WP_010668421.1 NC_016028:c20273-19998 [Komagataeibacter medellinensis NBRC 3288]
MTYVSYTDLRQNLAHYLDEAVNSRAPIVVTRKTGKGSVVLMSEEEFSGWQETVHLLSSPRNAERLLRSIRDIEHGAATEH
DLLEPQGEPSA

Download         Length: 276 bp

>AT25656 NC_016028:c20273-19998 [Komagataeibacter medellinensis NBRC 3288]
ATGACCTATGTTTCCTATACCGACCTGCGCCAGAACCTGGCGCATTATCTGGACGAAGCAGTGAACAGCCGTGCGCCGAT
TGTCGTGACCCGCAAGACCGGGAAAGGCAGTGTCGTGCTGATGTCGGAAGAAGAATTCTCCGGCTGGCAGGAAACCGTGC
ATCTCCTGAGCAGCCCACGCAACGCGGAGAGGCTGTTGCGGAGCATTCGTGACATCGAGCACGGGGCGGCAACCGAGCAT
GATCTTCTGGAGCCTCAGGGTGAACCGTCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A149R123

Antitoxin

Source ID Structure
AlphaFold DB A0A149R124

References