Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 623058..623785 Replicon chromosome
Accession NZ_CP103758
Organism Escherichia coli strain p10B

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag NYO15_RS03060 Protein ID WP_000550189.1
Coordinates 623058..623372 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYO15_RS03065 Protein ID WP_000560266.1
Coordinates 623369..623785 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO15_RS03040 (619225) 619225..620211 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
NYO15_RS03045 (620290) 620290..620973 - 684 WP_001183043.1 vancomycin high temperature exclusion protein -
NYO15_RS03050 (621050) 621050..621553 - 504 WP_001295542.1 M48 family metallopeptidase -
NYO15_RS03055 (621638) 621638..622774 + 1137 WP_000018681.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NYO15_RS03060 (623058) 623058..623372 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
NYO15_RS03065 (623369) 623369..623785 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NYO15_RS03070 (623830) 623830..625848 - 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NYO15_RS03075 (626274) 626274..628625 - 2352 WP_000695487.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T256559 WP_000550189.1 NZ_CP103758:623058-623372 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT256559 WP_000560266.1 NZ_CP103758:623369-623785 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References