Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 579721..580520 Replicon chromosome
Accession NZ_CP103758
Organism Escherichia coli strain p10B

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag NYO15_RS02835 Protein ID WP_000347275.1
Coordinates 579721..580185 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NYO15_RS02840 Protein ID WP_001307405.1
Coordinates 580185..580520 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO15_RS02805 (574722) 574722..575156 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NYO15_RS02810 (575174) 575174..576052 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NYO15_RS02815 (576042) 576042..576821 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
NYO15_RS02820 (576832) 576832..577305 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NYO15_RS02825 (577328) 577328..578608 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NYO15_RS02830 (578857) 578857..579666 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NYO15_RS02835 (579721) 579721..580185 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NYO15_RS02840 (580185) 580185..580520 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NYO15_RS02845 (580669) 580669..582240 - 1572 WP_001273752.1 galactarate dehydratase -
NYO15_RS02850 (582615) 582615..583949 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NYO15_RS02855 (583965) 583965..584735 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T256558 WP_000347275.1 NZ_CP103758:c580185-579721 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT256558 WP_001307405.1 NZ_CP103758:c580520-580185 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References