Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5084841..5085443 Replicon chromosome
Accession NZ_CP103755
Organism Escherichia coli strain p11B

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag NYO14_RS25190 Protein ID WP_000897302.1
Coordinates 5085132..5085443 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYO14_RS25185 Protein ID WP_000356397.1
Coordinates 5084841..5085131 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO14_RS25155 (5080148) 5080148..5081077 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
NYO14_RS25160 (5081259) 5081259..5081501 - 243 WP_001068514.1 CopG family transcriptional regulator -
NYO14_RS25165 (5081791) 5081791..5082639 + 849 WP_001038650.1 hypothetical protein -
NYO14_RS25170 (5082664) 5082664..5083404 + 741 WP_000608806.1 hypothetical protein -
NYO14_RS25175 (5083589) 5083589..5083807 - 219 WP_001251293.1 CopG family transcriptional regulator -
NYO14_RS25180 (5084204) 5084204..5084482 - 279 WP_001296612.1 hypothetical protein -
NYO14_RS25185 (5084841) 5084841..5085131 - 291 WP_000356397.1 NadS family protein Antitoxin
NYO14_RS25190 (5085132) 5085132..5085443 - 312 WP_000897302.1 hypothetical protein Toxin
NYO14_RS25195 (5085672) 5085672..5086580 + 909 WP_001385591.1 alpha/beta hydrolase -
NYO14_RS25200 (5086644) 5086644..5087585 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NYO14_RS25205 (5087630) 5087630..5088067 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
NYO14_RS25210 (5088064) 5088064..5088936 - 873 WP_000920762.1 virulence factor BrkB family protein -
NYO14_RS25215 (5088930) 5088930..5089529 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T256547 WP_000897302.1 NZ_CP103755:c5085443-5085132 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT256547 WP_000356397.1 NZ_CP103755:c5085131-5084841 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References