Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1934050..1934552 Replicon chromosome
Accession NZ_CP103755
Organism Escherichia coli strain p11B

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag NYO14_RS09205 Protein ID WP_000767819.1
Coordinates 1934298..1934552 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag NYO14_RS09200 Protein ID WP_001259253.1
Coordinates 1934050..1934301 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO14_RS09175 (1929228) 1929228..1930295 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NYO14_RS09180 (1930295) 1930295..1931365 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
NYO14_RS09185 (1931362) 1931362..1932666 - 1305 WP_001296211.1 histidinol dehydrogenase -
NYO14_RS09190 (1932672) 1932672..1933571 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NYO14_RS09195 (1933717) 1933717..1933767 - 51 WP_001364200.1 his operon leader peptide -
NYO14_RS09200 (1934050) 1934050..1934301 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NYO14_RS09205 (1934298) 1934298..1934552 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NYO14_RS09210 (1934635) 1934635..1935459 + 825 WP_000754737.1 SDR family oxidoreductase -
NYO14_RS09215 (1935505) 1935505..1936434 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NYO14_RS09220 (1936649) 1936649..1936711 + 63 WP_010723108.1 membrane protein YoeI -
NYO14_RS09225 (1936701) 1936701..1938059 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
NYO14_RS09230 (1938276) 1938276..1938734 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1938276..1938734 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T256531 WP_000767819.1 NZ_CP103755:1934298-1934552 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT256531 WP_001259253.1 NZ_CP103755:1934050-1934301 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References