Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1864426..1864928 Replicon chromosome
Accession NZ_CP103742
Organism Escherichia coli O25b:H4-ST131 strain 2822

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag M5R22_RS08775 Protein ID WP_000767822.1
Coordinates 1864674..1864928 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5R22_RS08770 Protein ID WP_001259255.1
Coordinates 1864426..1864677 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R22_RS08745 (1859604) 1859604..1860671 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5R22_RS08750 (1860671) 1860671..1861741 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
M5R22_RS08755 (1861738) 1861738..1863042 - 1305 WP_001546022.1 histidinol dehydrogenase -
M5R22_RS08760 (1863048) 1863048..1863947 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5R22_RS08765 (1864093) 1864093..1864143 - 51 WP_001364200.1 his operon leader peptide -
M5R22_RS08770 (1864426) 1864426..1864677 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5R22_RS08775 (1864674) 1864674..1864928 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5R22_RS08780 (1865011) 1865011..1865835 + 825 WP_000754737.1 SDR family oxidoreductase -
M5R22_RS08785 (1865881) 1865881..1866810 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M5R22_RS08790 (1867025) 1867025..1867087 + 63 WP_010723108.1 membrane protein YoeI -
M5R22_RS08795 (1867077) 1867077..1868435 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T256451 WP_000767822.1 NZ_CP103742:1864674-1864928 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT256451 WP_001259255.1 NZ_CP103742:1864426-1864677 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References