Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4215377..4216070 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag M5T33_RS20765 Protein ID WP_000415585.1
Coordinates 4215774..4216070 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5T33_RS20760 Protein ID WP_000650107.1
Coordinates 4215377..4215772 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS20750 (4211241) 4211241..4213499 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
M5T33_RS20755 (4213637) 4213637..4215244 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M5T33_RS20760 (4215377) 4215377..4215772 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5T33_RS20765 (4215774) 4215774..4216070 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
M5T33_RS20770 (4216275) 4216275..4216757 - 483 WP_000183505.1 GyrI-like domain-containing protein -
M5T33_RS20775 (4216810) 4216810..4217202 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5T33_RS20780 (4217354) 4217354..4218013 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
M5T33_RS20785 (4218010) 4218010..4219359 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
M5T33_RS20790 (4219405) 4219405..4219737 - 333 WP_000914690.1 DUF2645 family protein -
M5T33_RS20795 (4219744) 4219744..4220454 - 711 WP_000834030.1 hypothetical protein -
M5T33_RS20800 (4220457) 4220457..4220936 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T256439 WP_000415585.1 NZ_CP103739:c4216070-4215774 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT256439 WP_000650107.1 NZ_CP103739:c4215772-4215377 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References