Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741354..742129 Replicon chromosome
Accession NZ_CP103729
Organism Klebsiella pneumoniae strain 197

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag M5R33_RS03750 Protein ID WP_009308645.1
Coordinates 741644..742129 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M5R33_RS03745 Protein ID WP_004150912.1
Coordinates 741354..741647 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R33_RS03725 (736562) 736562..737164 - 603 WP_004174410.1 short chain dehydrogenase -
M5R33_RS03730 (737262) 737262..738173 + 912 WP_004181308.1 LysR family transcriptional regulator -
M5R33_RS03735 (738174) 738174..739322 - 1149 WP_023301497.1 PLP-dependent aspartate aminotransferase family protein -
M5R33_RS03740 (739333) 739333..740709 - 1377 WP_004181304.1 cystathionine beta-synthase -
M5R33_RS03745 (741354) 741354..741647 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M5R33_RS03750 (741644) 741644..742129 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
M5R33_RS03755 (742833) 742833..743426 + 594 WP_114265904.1 hypothetical protein -
M5R33_RS03760 (743523) 743523..743739 + 217 Protein_737 transposase -
M5R33_RS03770 (744580) 744580..745293 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743523..743675 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T256389 WP_009308645.1 NZ_CP103729:741644-742129 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT256389 WP_004150912.1 NZ_CP103729:741354-741647 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References