Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 353663..354309 Replicon chromosome
Accession NZ_CP103729
Organism Klebsiella pneumoniae strain 197

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5R33_RS01650 Protein ID WP_049117416.1
Coordinates 353663..353989 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M5R33_RS01655 Protein ID WP_002920557.1
Coordinates 354010..354309 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R33_RS01640 (349589) 349589..351022 + 1434 WP_002920564.1 glycogen synthase GlgA -
M5R33_RS01645 (351040) 351040..353487 + 2448 WP_002920561.1 glycogen phosphorylase -
M5R33_RS01650 (353663) 353663..353989 + 327 WP_049117416.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R33_RS01655 (354010) 354010..354309 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M5R33_RS01660 (354372) 354372..355880 - 1509 WP_064149756.1 glycerol-3-phosphate dehydrogenase -
M5R33_RS01665 (356085) 356085..356414 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M5R33_RS01670 (356465) 356465..357295 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M5R33_RS01675 (357345) 357345..358103 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12643.57 Da        Isoelectric Point: 5.1769

>T256388 WP_049117416.1 NZ_CP103729:353663-353989 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITMADREFS

Download         Length: 327 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT256388 WP_002920557.1 NZ_CP103729:354010-354309 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References