Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2359940..2360311 Replicon chromosome
Accession NZ_CP103718
Organism Escherichia coli strain 1579

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag M5S87_RS11375 Protein ID WP_001443846.1
Coordinates 2360162..2360311 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2359940..2360118 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S87_RS11350 (2355895) 2355895..2357268 + 1374 WP_000123748.1 ATP-dependent RNA helicase DbpA -
M5S87_RS11355 (2357397) 2357397..2358332 - 936 WP_001523172.1 tRNA 2-thiocytidine(32) synthetase TtcA -
M5S87_RS11360 (2358384) 2358384..2359619 - 1236 WP_000040839.1 site-specific integrase -
M5S87_RS11365 (2359621) 2359621..2359836 - 216 WP_000079604.1 excisionase XisR -
- (2359940) 2359940..2360118 + 179 NuclAT_0 - Antitoxin
- (2359940) 2359940..2360118 + 179 NuclAT_0 - Antitoxin
- (2359940) 2359940..2360118 + 179 NuclAT_0 - Antitoxin
- (2359940) 2359940..2360118 + 179 NuclAT_0 - Antitoxin
M5S87_RS11370 (2359936) 2359936..2360124 - 189 WP_001302840.1 DUF1187 family protein -
M5S87_RS11375 (2360162) 2360162..2360311 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
M5S87_RS11380 (2360367) 2360367..2361176 - 810 WP_000166313.1 recombination protein RecT -
M5S87_RS11385 (2361169) 2361169..2363769 - 2601 WP_000105140.1 exodeoxyribonuclease VIII -
M5S87_RS11390 (2363871) 2363871..2364146 - 276 WP_001344816.1 hypothetical protein -
M5S87_RS11395 (2364221) 2364221..2364391 - 171 WP_001352098.1 YdaE family protein -
M5S87_RS11400 (2364391) 2364391..2364612 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2358384..2409523 51139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T256326 WP_001443846.1 NZ_CP103718:c2360311-2360162 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

Antitoxin


Download         Length: 179 bp

>AT256326 NZ_CP103718:2359940-2360118 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References