Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3832543..3833140 Replicon chromosome
Accession NZ_CP103714
Organism Klebsiella pneumoniae strain ST15

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag M5T51_RS18710 Protein ID WP_004142563.1
Coordinates 3832823..3833140 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag M5T51_RS18705 Protein ID WP_004142561.1
Coordinates 3832543..3832830 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T51_RS18675 (3828623) 3828623..3828871 + 249 WP_020325243.1 DUF1158 domain-containing protein -
M5T51_RS18680 (3828889) 3828889..3829230 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
M5T51_RS18685 (3829261) 3829261..3830376 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
M5T51_RS18690 (3830556) 3830556..3831137 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
M5T51_RS18695 (3831137) 3831137..3831505 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
M5T51_RS18700 (3831625) 3831625..3832278 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
M5T51_RS18705 (3832543) 3832543..3832830 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
M5T51_RS18710 (3832823) 3832823..3833140 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T51_RS18715 (3833325) 3833325..3834368 - 1044 WP_020325241.1 DUF2157 domain-containing protein -
M5T51_RS18720 (3835038) 3835038..3835904 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
M5T51_RS18725 (3836013) 3836013..3837440 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T256311 WP_004142563.1 NZ_CP103714:c3833140-3832823 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT256311 WP_004142561.1 NZ_CP103714:c3832830-3832543 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References