Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 752616..753309 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M5T41_RS03635 Protein ID WP_000415584.1
Coordinates 752616..752912 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5T41_RS03640 Protein ID WP_000650107.1
Coordinates 752914..753309 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS03600 (747704) 747704..748018 - 315 WP_000958598.1 putative quinol monooxygenase -
M5T41_RS03605 (748049) 748049..748630 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M5T41_RS03610 (748949) 748949..749281 + 333 WP_000917684.1 DUF2645 family protein -
M5T41_RS03615 (749327) 749327..750676 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
M5T41_RS03620 (750673) 750673..751332 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M5T41_RS03625 (751484) 751484..751876 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5T41_RS03630 (751929) 751929..752411 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M5T41_RS03635 (752616) 752616..752912 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M5T41_RS03640 (752914) 752914..753309 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5T41_RS03645 (753442) 753442..755049 + 1608 WP_064221462.1 ABC transporter substrate-binding protein -
M5T41_RS03650 (755187) 755187..757445 + 2259 WP_104763973.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T256250 WP_000415584.1 NZ_CP103704:752616-752912 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT256250 WP_000650107.1 NZ_CP103704:752914-753309 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References