Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 639617..640416 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag M5T41_RS03085 Protein ID WP_000347251.1
Coordinates 639617..640081 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag M5T41_RS03090 Protein ID WP_001308975.1
Coordinates 640081..640416 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS03055 (634618) 634618..635052 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M5T41_RS03060 (635070) 635070..635948 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
M5T41_RS03065 (635938) 635938..636717 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M5T41_RS03070 (636728) 636728..637201 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M5T41_RS03075 (637224) 637224..638504 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
M5T41_RS03080 (638753) 638753..639562 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M5T41_RS03085 (639617) 639617..640081 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M5T41_RS03090 (640081) 640081..640416 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M5T41_RS03095 (640565) 640565..642136 - 1572 WP_064221457.1 galactarate dehydratase -
M5T41_RS03100 (642511) 642511..643845 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
M5T41_RS03105 (643861) 643861..644631 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T256248 WP_000347251.1 NZ_CP103704:c640081-639617 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT256248 WP_001308975.1 NZ_CP103704:c640416-640081 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References