Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4599312..4599958 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5R27_RS22090 Protein ID WP_032415766.1
Coordinates 4599312..4599659 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M5R27_RS22095 Protein ID WP_002920557.1
Coordinates 4599659..4599958 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS22080 (M5R27_22080) 4595238..4596671 + 1434 WP_002920564.1 glycogen synthase GlgA -
M5R27_RS22085 (M5R27_22085) 4596689..4599136 + 2448 WP_002920561.1 glycogen phosphorylase -
M5R27_RS22090 (M5R27_22090) 4599312..4599659 + 348 WP_032415766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R27_RS22095 (M5R27_22095) 4599659..4599958 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M5R27_RS22100 (M5R27_22100) 4600021..4601529 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
M5R27_RS22105 (M5R27_22105) 4601734..4602063 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M5R27_RS22110 (M5R27_22110) 4602114..4602944 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M5R27_RS22115 (M5R27_22115) 4602994..4603752 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13535.49 Da        Isoelectric Point: 5.2054

>T256229 WP_032415766.1 NZ_CP103697:4599312-4599659 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNENRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT256229 WP_002920557.1 NZ_CP103697:4599659-4599958 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References