256200

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1806859..1807361 Replicon chromosome
Accession NZ_CP103694
Organism Escherichia coli strain ST12468

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag M5T31_RS08710 Protein ID WP_000767833.1
Coordinates 1807107..1807361 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5T31_RS08705 Protein ID WP_001259255.1
Coordinates 1806859..1807110 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T31_RS08680 (1802038) 1802038..1803105 - 1068 WP_032202492.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5T31_RS08685 (1803105) 1803105..1804175 - 1071 WP_000108970.1 histidinol-phosphate transaminase -
M5T31_RS08690 (1804172) 1804172..1805476 - 1305 WP_058905757.1 histidinol dehydrogenase -
M5T31_RS08695 (1805482) 1805482..1806381 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5T31_RS08700 (1806527) 1806527..1806577 - 51 WP_001364200.1 his operon leader peptide -
M5T31_RS08705 (1806859) 1806859..1807110 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5T31_RS08710 (1807107) 1807107..1807361 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5T31_RS08715 (1807444) 1807444..1808268 + 825 WP_032202495.1 SDR family oxidoreductase -
M5T31_RS08720 (1808314) 1808314..1809243 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
M5T31_RS08725 (1809458) 1809458..1809520 + 63 WP_010723108.1 membrane protein YoeI -
M5T31_RS08730 (1809510) 1809510..1810868 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
M5T31_RS08735 (1811047) 1811047..1812105 + 1059 WP_259430762.1 thiosulfate utilization transporter TsuA/YeeE -
M5T31_RS08740 (1812119) 1812119..1812346 + 228 WP_000985278.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T256200 WP_000767833.1 NZ_CP103694:1807107-1807361 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT256200 WP_001259255.1 NZ_CP103694:1806859-1807110 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References