256197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 719907..720600 Replicon chromosome
Accession NZ_CP103694
Organism Escherichia coli strain ST12468

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M5T31_RS03505 Protein ID WP_000415584.1
Coordinates 719907..720203 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5T31_RS03510 Protein ID WP_000650107.1
Coordinates 720205..720600 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T31_RS03470 (714995) 714995..715309 - 315 WP_000958598.1 putative quinol monooxygenase -
M5T31_RS03475 (715340) 715340..715921 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M5T31_RS03480 (716240) 716240..716572 + 333 WP_000917684.1 DUF2645 family protein -
M5T31_RS03485 (716618) 716618..717967 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
M5T31_RS03490 (717964) 717964..718623 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M5T31_RS03495 (718775) 718775..719167 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5T31_RS03500 (719220) 719220..719702 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M5T31_RS03505 (719907) 719907..720203 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M5T31_RS03510 (720205) 720205..720600 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5T31_RS03515 (720733) 720733..722340 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M5T31_RS03520 (722478) 722478..724736 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T256197 WP_000415584.1 NZ_CP103694:719907-720203 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT256197 WP_000650107.1 NZ_CP103694:720205-720600 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References