Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3911111..3911699 Replicon chromosome
Accession NC_015947
Organism Stenotrophomonas maltophilia JV3

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BURJV3_RS17830 Protein ID WP_014038543.1
Coordinates 3911421..3911699 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BURJV3_RS17825 Protein ID WP_006471116.1
Coordinates 3911111..3911410 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURJV3_RS17805 3906540..3907733 + 1194 WP_198283169.1 pyridoxal phosphate-dependent aminotransferase -
BURJV3_RS17810 3907851..3909947 - 2097 WP_014038540.1 prolyl oligopeptidase family protein -
BURJV3_RS17815 3910017..3910340 - 324 WP_014038541.1 hypothetical protein -
BURJV3_RS17820 3910468..3911070 + 603 WP_014038542.1 lipocalin family protein -
BURJV3_RS17825 3911111..3911410 - 300 WP_006471116.1 HigA family addiction module antidote protein Antitoxin
BURJV3_RS17830 3911421..3911699 - 279 WP_014038543.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BURJV3_RS17835 3911905..3912594 - 690 WP_014038544.1 ABC transporter permease -
BURJV3_RS17840 3912591..3913598 - 1008 WP_014038545.1 methionine ABC transporter ATP-binding protein -
BURJV3_RS17845 3913809..3914705 - 897 WP_014038546.1 DMT family transporter -
BURJV3_RS17850 3914923..3915405 + 483 WP_014038547.1 YajQ family cyclic di-GMP-binding protein -
BURJV3_RS17855 3915507..3916073 + 567 WP_042358974.1 DUF1415 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10742.29 Da        Isoelectric Point: 10.4115

>T25619 WP_014038543.1 NC_015947:c3911699-3911421 [Stenotrophomonas maltophilia JV3]
MIRSFRCKQTRALFEGTCPRAWRQIRRVVERKLQLLDSAQTLAFLRSPPGSRLEALSGDRRGQYSLRINDQWRLCFTWTD
GGADAVEIVDYH

Download         Length: 279 bp

>T25619 NC_015947:c3911699-3911421 [Stenotrophomonas maltophilia JV3]
ATGATTCGTTCATTCCGCTGCAAGCAGACCCGCGCCCTGTTTGAAGGAACCTGCCCACGCGCCTGGCGCCAGATCCGGCG
AGTGGTGGAACGCAAACTGCAACTGCTCGACTCGGCACAGACGTTGGCTTTCCTCCGCAGCCCGCCCGGGAGCCGCCTCG
AGGCGCTGTCAGGCGATCGAAGAGGGCAGTACAGCCTTCGCATCAACGATCAATGGCGGCTCTGCTTTACCTGGACCGAC
GGCGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10869.59 Da        Isoelectric Point: 11.3450

>AT25619 WP_006471116.1 NC_015947:c3911410-3911111 [Stenotrophomonas maltophilia JV3]
MKRPHNGMRAIHPGEILREEFLLPLALSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT25619 NC_015947:c3911410-3911111 [Stenotrophomonas maltophilia JV3]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGCTGCCCTTGGCGCT
GAGCGTGAATGCGCTGGCGAAGGCGCTGGATGTGCCCGCAACGCGACTGCACGCCATCGTGCACGGCCAACGCAGCATTT
CGGCGGACACTGCAGCGCGGCTGGCGCGGCATTTTGGTGGGGATGCCGCGTCCTGGCTCGCGATGCAGGCGGCCTACGAT
CTCAAGACATTGCCAACGCGCAGCGAAATCGAACGCCGGGTGCAGCCACGCGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References