25618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3653479..3654709 Replicon chromosome
Accession NC_015945
Organism Muricauda ruestringensis DSM 13258

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag MURRU_RS16445 Protein ID WP_014034005.1
Coordinates 3653479..3654402 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag MURRU_RS16450 Protein ID WP_041801548.1
Coordinates 3654395..3654709 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MURRU_RS16420 3648880..3650073 - 1194 WP_014034612.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
MURRU_RS16425 3650088..3650840 - 753 WP_014034613.1 sulfite exporter TauE/SafE family protein -
MURRU_RS16435 3651331..3652560 + 1230 WP_014034614.1 site-specific integrase -
MURRU_RS16440 3652557..3653108 + 552 WP_187289864.1 site-specific integrase -
MURRU_RS17850 3653112..3653285 + 174 WP_148261533.1 winged helix-turn-helix transcriptional regulator -
MURRU_RS16445 3653479..3654402 - 924 WP_014034005.1 HipA domain-containing protein Toxin
MURRU_RS16450 3654395..3654709 - 315 WP_041801548.1 HipA N-terminal domain-containing protein Antitoxin
MURRU_RS16455 3654709..3654924 - 216 WP_014034003.1 helix-turn-helix transcriptional regulator -
MURRU_RS16460 3655335..3655517 - 183 WP_014034615.1 hypothetical protein -
MURRU_RS16465 3655888..3657324 - 1437 WP_014034616.1 DASS family sodium-coupled anion symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-277)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35191.80 Da        Isoelectric Point: 9.3528

>T25618 WP_014034005.1 NC_015945:c3654402-3653479 [Muricauda ruestringensis DSM 13258]
MNRCPITYELCGTAKYSGRGLKMIAPKLTDLKDLPYSAAELRRESANRAKKLSIQGVQPKLSATVSVVDQEFKIVDQFGT
YIIKPQNDLFPQLPENEDLTMRMAKAYGLNVPFHGMVYAKDGSLSYFIKRFDRYGKGKKYAVEDFAQLTGNTRDTKYRFT
MERVVPVVDEFCSFPVVEKADFFKRIIFCYVTGNEDMHLKNFSLITKNGKTTLAPAYDLLNSTISIKNPEEEIALTLKGK
KSNFIASDFIGYYAKERLQLNDRIIEVILGDMYQATPKWKELIAVSFLSDEMKEKYLNLLESRLKLF

Download         Length: 924 bp

>T25618 NC_015945:c3654402-3653479 [Muricauda ruestringensis DSM 13258]
ATGAATAGGTGCCCAATCACATACGAACTGTGCGGTACGGCGAAATACAGTGGGAGAGGACTAAAAATGATTGCACCCAA
ATTAACCGATCTGAAGGATTTACCCTATTCAGCAGCCGAATTGAGACGGGAATCAGCAAATAGGGCCAAGAAACTATCCA
TCCAAGGGGTACAACCTAAATTAAGTGCAACTGTTTCCGTGGTTGACCAGGAATTTAAAATTGTAGATCAATTCGGAACC
TACATCATAAAACCGCAAAATGATTTATTTCCCCAGTTGCCCGAAAATGAGGACCTGACCATGCGCATGGCTAAAGCCTA
TGGCTTGAATGTTCCATTTCATGGGATGGTATATGCCAAGGATGGCAGTCTCTCGTATTTTATAAAACGTTTCGATCGTT
ATGGCAAGGGAAAGAAATACGCTGTGGAGGATTTTGCACAATTAACGGGAAATACGAGGGATACCAAATACCGCTTTACC
ATGGAAAGAGTAGTTCCCGTTGTTGATGAGTTTTGTTCATTTCCCGTTGTTGAAAAGGCTGATTTTTTTAAAAGGATAAT
TTTCTGTTATGTAACTGGAAATGAGGATATGCATTTAAAAAACTTTTCCTTGATTACAAAAAACGGAAAAACCACCTTGG
CACCAGCCTATGATCTATTGAATTCCACAATTTCCATTAAAAATCCAGAAGAAGAAATCGCATTGACCTTAAAAGGAAAA
AAAAGCAATTTCATAGCATCGGATTTTATTGGTTATTATGCGAAAGAGCGATTACAATTGAATGATAGAATAATTGAAGT
GATTCTTGGGGACATGTATCAGGCAACTCCAAAATGGAAGGAGTTGATAGCAGTTTCTTTTCTTTCGGATGAAATGAAAG
AGAAATATCTAAATCTATTGGAGTCGAGATTGAAATTGTTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11743.41 Da        Isoelectric Point: 4.6413

>AT25618 WP_041801548.1 NC_015945:c3654709-3654395 [Muricauda ruestringensis DSM 13258]
MRKAVVYTHGKRAGVLTEVSPNEYHFDYDEDYDGDSISLTMPVSQKKYSFKSFPPFFEGLLPEGVMLQGLLRIVKIDQKD
YFSQLMATGADLVGAITVKPMEDE

Download         Length: 315 bp

>AT25618 NC_015945:c3654709-3654395 [Muricauda ruestringensis DSM 13258]
ATGAGAAAGGCAGTTGTATATACCCATGGCAAAAGAGCAGGAGTACTTACCGAAGTTTCTCCAAATGAATATCATTTTGA
TTATGATGAAGATTATGATGGAGATTCTATCTCATTGACCATGCCAGTAAGCCAGAAAAAATACAGTTTTAAATCATTCC
CCCCCTTTTTTGAAGGTTTGTTGCCTGAGGGTGTAATGTTGCAGGGGCTATTGAGGATTGTAAAAATTGATCAAAAGGAT
TATTTCTCACAATTAATGGCGACAGGTGCTGATCTGGTTGGTGCAATAACCGTAAAACCAATGGAGGATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References