Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1266921..1267648 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q486
Locus tag M5S84_RS06055 Protein ID WP_033486526.1
Coordinates 1267337..1267648 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q1H0
Locus tag M5S84_RS06050 Protein ID WP_045349893.1
Coordinates 1266921..1267340 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS06040 (M5S84_06040) 1264751..1265872 - 1122 WP_032670426.1 YbdK family carboxylate-amine ligase -
M5S84_RS06045 (M5S84_06045) 1265978..1266868 + 891 WP_033486528.1 oxidoreductase -
M5S84_RS06050 (M5S84_06050) 1266921..1267340 - 420 WP_045349893.1 helix-turn-helix domain-containing protein Antitoxin
M5S84_RS06055 (M5S84_06055) 1267337..1267648 - 312 WP_033486526.1 type II toxin-antitoxin system HigB family toxin Toxin
M5S84_RS06060 (M5S84_06060) 1268070..1270190 - 2121 WP_033486523.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12506.30 Da        Isoelectric Point: 9.9435

>T256163 WP_033486526.1 NZ_CP103683:c1267648-1267337 [Enterobacter hormaechei]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLTDYYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15375.45 Da        Isoelectric Point: 4.7132

>AT256163 WP_045349893.1 NZ_CP103683:c1267340-1266921 [Enterobacter hormaechei]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVDMLTAKIDKYENASPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q486

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q1H0

References