Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5176615..5177217 Replicon chromosome
Accession NZ_CP103672
Organism Escherichia coli O25b:H4-ST131 strain 4433

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag M5S92_RS25705 Protein ID WP_000897302.1
Coordinates 5176906..5177217 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S92_RS25700 Protein ID WP_000356397.1
Coordinates 5176615..5176905 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S92_RS25670 (5171922) 5171922..5172851 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
M5S92_RS25675 (5173033) 5173033..5173275 - 243 WP_001068514.1 CopG family transcriptional regulator -
M5S92_RS25680 (5173565) 5173565..5174413 + 849 WP_001038650.1 hypothetical protein -
M5S92_RS25685 (5174438) 5174438..5175178 + 741 WP_000608806.1 hypothetical protein -
M5S92_RS25690 (5175363) 5175363..5175581 - 219 WP_001251293.1 CopG family transcriptional regulator -
M5S92_RS25695 (5175978) 5175978..5176256 - 279 WP_001296612.1 hypothetical protein -
M5S92_RS25700 (5176615) 5176615..5176905 - 291 WP_000356397.1 NadS family protein Antitoxin
M5S92_RS25705 (5176906) 5176906..5177217 - 312 WP_000897302.1 hypothetical protein Toxin
M5S92_RS25710 (5177446) 5177446..5178354 + 909 WP_001385591.1 alpha/beta hydrolase -
M5S92_RS25715 (5178418) 5178418..5179359 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5S92_RS25720 (5179404) 5179404..5179841 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
M5S92_RS25725 (5179838) 5179838..5180710 - 873 WP_000920762.1 virulence factor BrkB family protein -
M5S92_RS25730 (5180704) 5180704..5181303 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T256091 WP_000897302.1 NZ_CP103672:c5177217-5176906 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT256091 WP_000356397.1 NZ_CP103672:c5176905-5176615 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References