Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 351841..352487 Replicon chromosome
Accession NZ_CP103654
Organism Klebsiella pneumoniae strain 1159

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag M5S75_RS01625 Protein ID WP_016529833.1
Coordinates 351841..352188 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M5S75_RS01630 Protein ID WP_002920557.1
Coordinates 352188..352487 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S75_RS01615 (347777) 347777..349210 + 1434 WP_002920564.1 glycogen synthase GlgA -
M5S75_RS01620 (349228) 349228..351675 + 2448 WP_002920561.1 glycogen phosphorylase -
M5S75_RS01625 (351841) 351841..352188 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S75_RS01630 (352188) 352188..352487 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M5S75_RS01635 (352550) 352550..354058 - 1509 WP_259418820.1 glycerol-3-phosphate dehydrogenase -
M5S75_RS01640 (354263) 354263..354592 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M5S75_RS01645 (354643) 354643..355473 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M5S75_RS01650 (355523) 355523..356281 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T256025 WP_016529833.1 NZ_CP103654:351841-352188 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT256025 WP_002920557.1 NZ_CP103654:352188-352487 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References