Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2085492..2085896 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACIFE_RS16390 Protein ID WP_081463255.1
Coordinates 2085783..2085896 (-) Length 38 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ACIFE_RS10155 Protein ID WP_014029486.1
Coordinates 2085492..2085773 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS10135 2081201..2081653 - 453 Protein_2023 hypothetical protein -
ACIFE_RS17230 2081540..2081788 + 249 WP_162470194.1 hypothetical protein -
ACIFE_RS17235 2081837..2082013 - 177 WP_014029482.1 hypothetical protein -
ACIFE_RS10140 2082035..2082391 - 357 WP_014029483.1 hypothetical protein -
ACIFE_RS10145 2082373..2082660 - 288 WP_041651016.1 hypothetical protein -
ACIFE_RS16385 2083200..2083382 - 183 WP_202796616.1 transposase -
ACIFE_RS10150 2083451..2085016 - 1566 WP_049786851.1 chloride channel protein -
ACIFE_RS10155 2085492..2085773 - 282 WP_014029486.1 HigA family addiction module antidote protein Antitoxin
ACIFE_RS16390 2085783..2085896 - 114 WP_081463255.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACIFE_RS10160 2086046..2086735 - 690 WP_014029487.1 pirin-like bicupin family protein -
ACIFE_RS10165 2086959..2087528 + 570 WP_143217870.1 lytic transglycosylase domain-containing protein -
ACIFE_RS10170 2087552..2088076 - 525 WP_014029489.1 hypothetical protein -
ACIFE_RS10175 2088261..2090666 - 2406 WP_014029490.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-37)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 4392.85 Da        Isoelectric Point: 4.3200

>T25601 WP_081463255.1 NC_015942:c2085896-2085783 [Acidithiobacillus ferrivorans SS3]
MMGDLEGFWSVSVNGNWRLTFRFDGNHAELVDYLDYH

Download         Length: 114 bp

>T25601 NC_015942:c2085896-2085783 [Acidithiobacillus ferrivorans SS3]
ATGATGGGTGACCTTGAGGGATTCTGGTCGGTGAGCGTGAATGGAAACTGGCGACTGACCTTTCGTTTCGACGGTAATCA
TGCAGAATTGGTTGATTATTTGGATTATCACTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10075.50 Da        Isoelectric Point: 7.2030

>AT25601 WP_014029486.1 NC_015942:c2085773-2085492 [Acidithiobacillus ferrivorans SS3]
MSEMHNPAHPGEVLREYLPEGMSVTDAAKALNVTRQALSALLNGRSGVSAEMALRLEAALGVEAGFWLRTQVAYDLWEAR
QRGVARGVRNIAA

Download         Length: 282 bp

>AT25601 NC_015942:c2085773-2085492 [Acidithiobacillus ferrivorans SS3]
ATGAGCGAAATGCACAATCCCGCACACCCCGGAGAGGTGTTGCGTGAATACTTGCCGGAGGGTATGAGTGTCACCGACGC
TGCAAAGGCGCTGAACGTGACTAGGCAGGCCTTGTCCGCGCTATTAAATGGACGGTCTGGCGTCAGTGCAGAGATGGCGC
TACGTCTCGAAGCAGCACTTGGTGTGGAAGCGGGGTTCTGGTTGCGAACGCAGGTGGCTTACGACCTCTGGGAGGCGCGG
CAGCGGGGAGTGGCTAGAGGCGTTCGAAACATCGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References