Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1846257..1846759 Replicon chromosome
Accession NZ_CP103645
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag M5R18_RS08875 Protein ID WP_000767831.1
Coordinates 1846505..1846759 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5R18_RS08870 Protein ID WP_001259255.1
Coordinates 1846257..1846508 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS08845 (1841434) 1841434..1842501 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5R18_RS08850 (1842501) 1842501..1843571 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
M5R18_RS08855 (1843568) 1843568..1844872 - 1305 WP_001446927.1 histidinol dehydrogenase -
M5R18_RS08860 (1844878) 1844878..1845777 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5R18_RS08865 (1845923) 1845923..1845973 - 51 WP_001364200.1 his operon leader peptide -
M5R18_RS08870 (1846257) 1846257..1846508 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5R18_RS08875 (1846505) 1846505..1846759 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5R18_RS08880 (1846842) 1846842..1847666 + 825 WP_000754737.1 SDR family oxidoreductase -
M5R18_RS08885 (1847712) 1847712..1848641 + 930 WP_024195433.1 LysR substrate-binding domain-containing protein -
M5R18_RS08890 (1848856) 1848856..1848918 + 63 WP_010723108.1 membrane protein YoeI -
M5R18_RS08895 (1848908) 1848908..1850266 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
M5R18_RS08900 (1850445) 1850445..1851503 + 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
M5R18_RS08905 (1851517) 1851517..1851744 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T255998 WP_000767831.1 NZ_CP103645:1846505-1846759 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255998 WP_001259255.1 NZ_CP103645:1846257-1846508 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References