Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4990700..4991302 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M5S90_RS24000 Protein ID WP_000897305.1
Coordinates 4990991..4991302 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S90_RS23995 Protein ID WP_000356395.1
Coordinates 4990700..4990990 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS23960 (4986323) 4986323..4987225 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M5S90_RS23965 (4987222) 4987222..4987857 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M5S90_RS23970 (4987854) 4987854..4988783 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
M5S90_RS23975 (4988965) 4988965..4989207 - 243 WP_021523315.1 hypothetical protein -
M5S90_RS23980 (4989426) 4989426..4989644 - 219 WP_001295676.1 CopG family transcriptional regulator -
M5S90_RS23985 (4990063) 4990063..4990341 - 279 WP_001306650.1 hypothetical protein -
M5S90_RS23990 (4990403) 4990403..4990615 - 213 WP_000197769.1 hypothetical protein -
M5S90_RS23995 (4990700) 4990700..4990990 - 291 WP_000356395.1 NadS family protein Antitoxin
M5S90_RS24000 (4990991) 4990991..4991302 - 312 WP_000897305.1 hypothetical protein Toxin
M5S90_RS24005 (4991531) 4991531..4992439 + 909 WP_001306651.1 alpha/beta hydrolase -
M5S90_RS24010 (4992608) 4992608..4993522 - 915 WP_077634137.1 transposase -
M5S90_RS24015 (4993535) 4993535..4994422 - 888 Protein_4694 hypothetical protein -
M5S90_RS24020 (4994838) 4994838..4995779 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5S90_RS24025 (4995824) 4995824..4996261 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T255947 WP_000897305.1 NZ_CP103633:c4991302-4990991 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT255947 WP_000356395.1 NZ_CP103633:c4990990-4990700 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References