255900

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1856856..1857358 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag M5S78_RS08885 Protein ID WP_000767829.1
Coordinates 1857104..1857358 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5S78_RS08880 Protein ID WP_001259255.1
Coordinates 1856856..1857107 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS08855 (1852034) 1852034..1853101 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5S78_RS08860 (1853101) 1853101..1854171 - 1071 WP_001362957.1 histidinol-phosphate transaminase -
M5S78_RS08865 (1854168) 1854168..1855472 - 1305 WP_001774536.1 histidinol dehydrogenase -
M5S78_RS08870 (1855478) 1855478..1856377 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5S78_RS08875 (1856523) 1856523..1856573 - 51 WP_001364200.1 his operon leader peptide -
M5S78_RS08880 (1856856) 1856856..1857107 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5S78_RS08885 (1857104) 1857104..1857358 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5S78_RS08890 (1857441) 1857441..1858265 + 825 WP_000754758.1 SDR family oxidoreductase -
M5S78_RS08895 (1858311) 1858311..1859240 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
M5S78_RS08900 (1859455) 1859455..1859517 + 63 WP_010723108.1 membrane protein YoeI -
M5S78_RS08905 (1859507) 1859507..1860865 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
M5S78_RS08910 (1861044) 1861044..1862102 + 1059 WP_000492315.1 thiosulfate utilization transporter TsuA/YeeE -
M5S78_RS08915 (1862116) 1862116..1862343 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T255900 WP_000767829.1 NZ_CP103626:1857104-1857358 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255900 WP_001259255.1 NZ_CP103626:1856856-1857107 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References