Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 724375..725068 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M5S78_RS03535 Protein ID WP_000415584.1
Coordinates 724375..724671 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5S78_RS03540 Protein ID WP_000650107.1
Coordinates 724673..725068 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS03505 (720050) 720050..720364 - 315 WP_000958598.1 putative quinol monooxygenase -
M5S78_RS03510 (720395) 720395..720976 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M5S78_RS03515 (721086) 721086..722435 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
M5S78_RS03520 (722432) 722432..723091 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
M5S78_RS03525 (723243) 723243..723635 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5S78_RS03530 (723688) 723688..724170 + 483 WP_000183494.1 GyrI-like domain-containing protein -
M5S78_RS03535 (724375) 724375..724671 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M5S78_RS03540 (724673) 724673..725068 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5S78_RS03545 (725201) 725201..726808 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
M5S78_RS03550 (726946) 726946..729204 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 712648..725068 12420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T255895 WP_000415584.1 NZ_CP103626:724375-724671 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT255895 WP_000650107.1 NZ_CP103626:724673-725068 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References