Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3684700..3685241 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag M5T36_RS17835 Protein ID WP_000615982.1
Coordinates 3684963..3685241 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag M5T36_RS17830 Protein ID WP_000729704.1
Coordinates 3684700..3684960 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS17805 (3680483) 3680483..3681268 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
M5T36_RS17810 (3681240) 3681240..3682952 + 1713 Protein_3485 flagellar biosynthesis protein FlhA -
M5T36_RS17815 (3683057) 3683057..3683335 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
M5T36_RS17820 (3683328) 3683328..3683684 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
M5T36_RS17825 (3683741) 3683741..3684514 - 774 WP_000543899.1 C40 family peptidase -
M5T36_RS17830 (3684700) 3684700..3684960 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
M5T36_RS17835 (3684963) 3684963..3685241 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
M5T36_RS17840 (3685397) 3685397..3686137 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
M5T36_RS17845 (3686108) 3686108..3686875 - 768 WP_000333380.1 class II glutamine amidotransferase -
M5T36_RS17850 (3687081) 3687081..3687659 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T255885 WP_000615982.1 NZ_CP103623:3684963-3685241 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT255885 WP_000729704.1 NZ_CP103623:3684700-3684960 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References