Detailed information of TA system TA025587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 422545..423262
• Replicon: chromosome
• Accession: NC_015942
• Organism: Acidithiobacillus ferrivorans SS3

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: G0JSS8
• Locus tag: ACIFE_RS01960
• Protein ID: WP_014027906.1
• Coordinates: 422960..423262 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: G0JSS7
• Locus tag: ACIFE_RS01955
• Protein ID: WP_014027905.1
• Coordinates: 422545..422958 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIFE_RS01920	417797..419287	-	1491	WP_041648384.1	ParB N-terminal domain-containing protein	-
ACIFE_RS01925	419284..419469	-	186	WP_014027901.1	hypothetical protein	-
ACIFE_RS01930	419456..419689	-	234	WP_041648388.1	hypothetical protein	-
ACIFE_RS01935	419676..419903	-	228	WP_014027902.1	hypothetical protein	-
ACIFE_RS01940	420046..421002	-	957	WP_014027903.1	hypothetical protein	-
ACIFE_RS15765	421448..421876	-	429	WP_014027904.1	helix-turn-helix transcriptional regulator	-
ACIFE_RS16055	422012..422188	+	177	WP_158306915.1	helix-turn-helix domain-containing protein	-
ACIFE_RS01955	422545..422958	-	414	WP_014027905.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ACIFE_RS01960	422960..423262	-	303	WP_014027906.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ACIFE_RS01965	423394..423825	+	432	WP_014027907.1	hypothetical protein	-
ACIFE_RS01970	423830..424123	+	294	WP_014027908.1	DUF1376 domain-containing protein	-
ACIFE_RS01975	424110..424331	+	222	WP_014027909.1	hypothetical protein	-
ACIFE_RS15770	424334..425332	+	999	WP_014027910.1	hypothetical protein	-
ACIFE_RS01990	425344..426183	+	840	WP_014027911.1	ATP-binding protein	-
ACIFE_RS01995	426132..426650	+	519	WP_158306916.1	hypothetical protein	-
ACIFE_RS02000	426654..427121	+	468	WP_014027913.1	lytic transglycosylase domain-containing protein	-
ACIFE_RS02005	427118..427741	+	624	WP_014027914.1	DotI/IcmL/TraM family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	283765..484935	201170

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-99)

Antitoxin

• Zinc finger, MqsA-type (7-52)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10905.84 Da
• Isoelectric Point: 8.9555

>T25587 WP_014027906.1 NC_015942:c423262-422960 [Acidithiobacillus ferrivorans SS3]
MEKRKAHYSLPEIKASVARLGIGAFTATALQGLDLMGLSPPDGLAVVLGLQPEMLFKSMTTYADSQVWQDVFHAICPNGK
TAYIKITLRPGTVVIQFKEL

Nucleotide

• Length: 303 bp

>T25587 NC_015942:c423262-422960 [Acidithiobacillus ferrivorans SS3]
ATGGAGAAACGAAAAGCTCACTACTCCCTGCCAGAGATCAAGGCATCTGTTGCTCGCCTTGGGATCGGCGCTTTTACCGC
TACCGCTTTGCAGGGACTGGATCTGATGGGTCTTTCTCCGCCCGACGGTCTGGCCGTTGTGTTGGGCCTGCAACCGGAAA
TGCTGTTCAAAAGCATGACCACTTACGCGGATAGCCAGGTATGGCAGGATGTTTTTCACGCCATCTGTCCCAACGGGAAA
ACAGCCTACATCAAAATCACGTTGCGCCCGGGGACAGTGGTGATTCAGTTCAAGGAGCTTTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15036.24 Da
• Isoelectric Point: 8.0550

>AT25587 WP_014027905.1 NC_015942:c422958-422545 [Acidithiobacillus ferrivorans SS3]
MTGKRFCLQCDDGTELVHERKDMIISVDGLTVTVPAIAGWHCPVCGECEFDAGEAQRYADALSALRKDAATRQGQALRAA
RKRLHLSQKDAGLLFGGGASAFSEYERGKTQPHKSTVLLLKLLEKHPELMNEIRRAG

Nucleotide

• Length: 414 bp

>AT25587 NC_015942:c422958-422545 [Acidithiobacillus ferrivorans SS3]
ATGACAGGAAAACGCTTTTGCTTGCAGTGCGACGACGGCACGGAACTCGTGCATGAGCGCAAGGACATGATCATTTCCGT
GGATGGCTTGACCGTTACCGTACCGGCCATCGCCGGATGGCATTGTCCGGTCTGCGGAGAATGCGAATTTGATGCGGGTG
AAGCGCAGCGGTATGCAGACGCGTTGAGCGCGTTGCGCAAGGATGCCGCCACCCGCCAGGGGCAGGCGTTACGCGCAGCG
CGTAAACGTCTGCACCTGAGCCAGAAAGATGCCGGACTGCTGTTCGGCGGCGGCGCGTCCGCGTTTTCCGAATACGAGCG
CGGCAAGACCCAACCCCATAAGTCCACGGTCCTCTTGCTAAAGCTGCTCGAAAAGCATCCGGAACTCATGAACGAGATCA
GGCGGGCGGGATAA

Structures

Toxin

• AlphaFold DB: G0JSS8

Antitoxin

• AlphaFold DB: G0JSS7