Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 146109..146744 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACIFE_RS00605 Protein ID WP_049786821.1
Coordinates 146109..146393 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACIFE_RS00610 Protein ID WP_014027638.1
Coordinates 146445..146744 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS00580 141484..142743 - 1260 WP_014027633.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
ACIFE_RS00585 142857..143171 - 315 WP_014027634.1 DUF190 domain-containing protein -
ACIFE_RS00590 143182..143559 - 378 WP_014027635.1 fluoride efflux transporter CrcB -
ACIFE_RS00595 143605..143846 - 242 Protein_119 NADH-quinone oxidoreductase subunit H -
ACIFE_RS00600 143989..145729 - 1741 Protein_120 glycosyltransferase family 39 protein -
ACIFE_RS00605 146109..146393 + 285 WP_049786821.1 hypothetical protein Toxin
ACIFE_RS00610 146445..146744 + 300 WP_014027638.1 helix-turn-helix domain-containing protein Antitoxin
ACIFE_RS00615 146887..148095 - 1209 WP_158306910.1 glycosyltransferase family 4 protein -
ACIFE_RS00620 148287..149114 - 828 WP_014027640.1 class I SAM-dependent methyltransferase -
ACIFE_RS00625 149115..150566 - 1452 WP_148260353.1 flippase -
ACIFE_RS00635 150853..151431 + 579 WP_014027643.1 peptidoglycan-associated lipoprotein Pal -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-72)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10415.09 Da        Isoelectric Point: 10.0544

>T25585 WP_049786821.1 NC_015942:146109-146393 [Acidithiobacillus ferrivorans SS3]
MFRLPASNLANHTLAAYDNYMVIVESPVFTKAIVAILDDEGYRAMQNALVENPALGVVIPHGGGLRKVRWGVEGRGKRGG
IRVIYYWWTGKGQI

Download         Length: 285 bp

>T25585 NC_015942:146109-146393 [Acidithiobacillus ferrivorans SS3]
TTGTTTCGGCTTCCCGCATCAAATCTTGCCAACCATACGCTTGCAGCGTATGATAACTACATGGTCATCGTCGAGTCACC
CGTATTCACCAAAGCCATCGTGGCCATCCTCGATGATGAGGGATACCGAGCCATGCAAAATGCATTGGTAGAGAACCCCG
CATTGGGCGTGGTGATTCCCCATGGCGGTGGTCTACGCAAGGTGCGGTGGGGAGTCGAAGGCAGGGGAAAGCGTGGAGGG
ATTCGCGTGATCTACTACTGGTGGACGGGCAAGGGTCAGATCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11064.65 Da        Isoelectric Point: 10.2881

>AT25585 WP_014027638.1 NC_015942:146445-146744 [Acidithiobacillus ferrivorans SS3]
MNEQGFDELLDSVRWMGRHMRGEDDNGRTTRIPDPDVKAIRETTGLSQSQFALMIGVKLKTLQNWEQKRVRPAGPARALL
QIVAVDPHAAIRALHGHAA

Download         Length: 300 bp

>AT25585 NC_015942:146445-146744 [Acidithiobacillus ferrivorans SS3]
ATGAATGAGCAAGGATTTGACGAACTGCTGGATAGTGTGCGCTGGATGGGCCGTCATATGCGCGGCGAGGATGATAACGG
GCGGACGACCCGCATTCCGGATCCTGATGTGAAGGCTATCCGTGAAACCACAGGGCTTTCTCAGTCGCAGTTCGCCCTGA
TGATTGGGGTCAAGCTCAAGACCTTGCAGAATTGGGAGCAGAAGCGGGTACGTCCGGCAGGGCCAGCTAGGGCGCTTTTG
CAGATCGTGGCTGTGGATCCCCATGCGGCGATTCGTGCCCTGCACGGCCACGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References