Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 358471..359117 Replicon chromosome
Accession NZ_CP103614
Organism Klebsiella pneumoniae strain 3571

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag M5T29_RS01665 Protein ID WP_004174016.1
Coordinates 358471..358818 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag M5T29_RS01670 Protein ID WP_004174017.1
Coordinates 358818..359117 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T29_RS01655 (M5T29_01655) 354397..355830 + 1434 WP_002920564.1 glycogen synthase GlgA -
M5T29_RS01660 (M5T29_01660) 355848..358295 + 2448 WP_002920561.1 glycogen phosphorylase -
M5T29_RS01665 (M5T29_01665) 358471..358818 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T29_RS01670 (M5T29_01670) 358818..359117 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
M5T29_RS01675 (M5T29_01675) 359180..360688 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
M5T29_RS01680 (M5T29_01680) 360893..361222 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M5T29_RS01685 (M5T29_01685) 361273..362103 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M5T29_RS01690 (M5T29_01690) 362153..362911 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T255827 WP_004174016.1 NZ_CP103614:358471-358818 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT255827 WP_004174017.1 NZ_CP103614:358818-359117 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References