Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4862720..4863322 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1AN02
Locus tag M5S62_RS23190 Protein ID WP_013099360.1
Coordinates 4863011..4863322 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S62_RS23185 Protein ID WP_013099359.1
Coordinates 4862720..4863010 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS23170 (M5S62_23170) 4860217..4861119 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
M5S62_RS23175 (M5S62_23175) 4861116..4861751 + 636 WP_023622447.1 formate dehydrogenase cytochrome b556 subunit -
M5S62_RS23180 (M5S62_23180) 4861748..4862677 + 930 WP_095428069.1 formate dehydrogenase accessory protein FdhE -
M5S62_RS23185 (M5S62_23185) 4862720..4863010 - 291 WP_013099359.1 helix-turn-helix domain-containing protein Antitoxin
M5S62_RS23190 (M5S62_23190) 4863011..4863322 - 312 WP_013099360.1 hypothetical protein Toxin
M5S62_RS23195 (M5S62_23195) 4863552..4864469 + 918 WP_259387503.1 alpha/beta hydrolase -
M5S62_RS23200 (M5S62_23200) 4864482..4865423 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
M5S62_RS23205 (M5S62_23205) 4865468..4865905 - 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
M5S62_RS23210 (M5S62_23210) 4865902..4866783 - 882 WP_013099364.1 virulence factor BrkB family protein -
M5S62_RS23215 (M5S62_23215) 4866777..4867376 - 600 WP_013099365.1 glucose-1-phosphatase -
M5S62_RS23220 (M5S62_23220) 4867496..4868296 - 801 WP_020686879.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12210.18 Da        Isoelectric Point: 9.7550

>T255822 WP_013099360.1 NZ_CP103611:c4863322-4863011 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLATQPDYGDLIQNTGGLRKIRWLSGGRGKRGGVRVIYFHRTHEFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10623.13 Da        Isoelectric Point: 10.4747

>AT255822 WP_013099359.1 NZ_CP103611:c4863010-4862720 [Enterobacter cloacae]
MDKALFERLTQSIAQMDDIVGGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVISALSD

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AN02

Antitoxin

Source ID Structure

References