Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 602054..602853 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag M5T19_RS02950 Protein ID WP_000347275.1
Coordinates 602054..602518 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag M5T19_RS02955 Protein ID WP_001307405.1
Coordinates 602518..602853 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS02920 (597055) 597055..597489 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M5T19_RS02925 (597507) 597507..598385 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M5T19_RS02930 (598375) 598375..599154 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
M5T19_RS02935 (599165) 599165..599638 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
M5T19_RS02940 (599661) 599661..600941 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
M5T19_RS02945 (601190) 601190..601999 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M5T19_RS02950 (602054) 602054..602518 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M5T19_RS02955 (602518) 602518..602853 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M5T19_RS02960 (603002) 603002..604573 - 1572 WP_001273752.1 galactarate dehydratase -
M5T19_RS02965 (604948) 604948..606282 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
M5T19_RS02970 (606298) 606298..607068 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T255752 WP_000347275.1 NZ_CP103596:c602518-602054 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT255752 WP_001307405.1 NZ_CP103596:c602853-602518 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References