Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4883667..4884269 Replicon chromosome
Accession NZ_CP103592
Organism Escherichia coli O25b:H4-ST131 strain 4224

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag M5S53_RS23930 Protein ID WP_000897302.1
Coordinates 4883958..4884269 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S53_RS23925 Protein ID WP_000356397.1
Coordinates 4883667..4883957 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S53_RS23895 (4878974) 4878974..4879903 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
M5S53_RS23900 (4880085) 4880085..4880327 - 243 WP_001068514.1 CopG family transcriptional regulator -
M5S53_RS23905 (4880617) 4880617..4881465 + 849 WP_001038650.1 hypothetical protein -
M5S53_RS23910 (4881490) 4881490..4882230 + 741 WP_000608806.1 hypothetical protein -
M5S53_RS23915 (4882415) 4882415..4882633 - 219 WP_001251293.1 CopG family transcriptional regulator -
M5S53_RS23920 (4883030) 4883030..4883308 - 279 WP_001296612.1 hypothetical protein -
M5S53_RS23925 (4883667) 4883667..4883957 - 291 WP_000356397.1 NadS family protein Antitoxin
M5S53_RS23930 (4883958) 4883958..4884269 - 312 WP_000897302.1 hypothetical protein Toxin
M5S53_RS23935 (4884498) 4884498..4885406 + 909 WP_001385591.1 alpha/beta hydrolase -
M5S53_RS23940 (4885470) 4885470..4886411 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5S53_RS23945 (4886456) 4886456..4886893 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
M5S53_RS23950 (4886890) 4886890..4887762 - 873 WP_000920762.1 virulence factor BrkB family protein -
M5S53_RS23955 (4887756) 4887756..4888355 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T255742 WP_000897302.1 NZ_CP103592:c4884269-4883958 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT255742 WP_000356397.1 NZ_CP103592:c4883957-4883667 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References