Detailed information of TA system TA025572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 4199056..4199731
• Replicon: chromosome
• Accession: NC_015856
• Organism: Collimonas fungivorans Ter331

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CFU_RS18700
• Protein ID: WP_014007572.1
• Coordinates: 4199357..4199731 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A127R352
• Locus tag: CFU_RS18695
• Protein ID: WP_041742396.1
• Coordinates: 4199056..4199340 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFU_RS18685	4194376..4196598	-	2223	WP_014007570.1	type I secretion system permease/ATPase	-
CFU_RS18690	4197142..4198662	-	1521	WP_041742394.1	hypothetical protein	-
CFU_RS18695	4199056..4199340	-	285	WP_041742396.1	helix-turn-helix domain-containing protein	Antitoxin
CFU_RS18700	4199357..4199731	-	375	WP_014007572.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFU_RS18705	4199984..4200346	-	363	WP_148264885.1	hypothetical protein	-
CFU_RS18710	4200774..4201781	-	1008	WP_041743679.1	DUF475 domain-containing protein	-
CFU_RS18715	4202170..4203126	-	957	WP_014007575.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (30-117)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-90)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14440.11 Da
• Isoelectric Point: 10.4209

>T25572 WP_014007572.1 NC_015856:c4199731-4199357 [Collimonas fungivorans Ter331]
MRLQKYTSNCNKYVIIEYQVSYYSQQIQADIMSLPATLQARYLSLTARMKIYGPHLGEPHTKVLGNGLLELRLKGAEGIA
RVFYCTMVGKQIVMLHSFVKKTQKIPFKEKRIAEIRMREVKNER

Nucleotide

• Length: 375 bp

>T25572 NC_015856:c4199731-4199357 [Collimonas fungivorans Ter331]
ATGAGGTTACAGAAATACACGTCAAATTGTAACAAATATGTTATTATCGAATATCAGGTTAGTTACTATAGCCAACAGAT
CCAGGCAGACATTATGTCCTTGCCGGCAACGCTGCAGGCACGCTATCTCAGCTTGACCGCCAGAATGAAGATTTACGGCC
CTCATTTGGGGGAGCCTCATACCAAGGTGCTTGGCAATGGCTTGCTTGAGTTACGCTTGAAGGGCGCGGAAGGCATTGCC
CGTGTTTTTTATTGCACGATGGTCGGGAAGCAGATTGTCATGCTGCACAGTTTCGTCAAGAAGACACAAAAAATTCCTTT
TAAGGAAAAACGGATTGCAGAAATTCGCATGAGGGAAGTTAAAAATGAGCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10397.00 Da
• Isoelectric Point: 9.7320

>AT25572 WP_041742396.1 NC_015856:c4199340-4199056 [Collimonas fungivorans Ter331]
MTHEEMQARMLQNPVVQAEYERLNREEFAILDEILAARKAAGLTQAQIAERMGTKAPAVARLESSLASGKHSPSINTLRK
YAAALGKRLEVHLV

Nucleotide

• Length: 285 bp

>AT25572 NC_015856:c4199340-4199056 [Collimonas fungivorans Ter331]
ATGACGCATGAAGAAATGCAGGCTCGGATGCTGCAGAATCCCGTTGTCCAGGCTGAATACGAACGCTTGAATCGCGAGGA
GTTTGCCATTCTTGACGAAATTTTAGCGGCACGCAAAGCGGCTGGACTCACCCAGGCACAGATTGCCGAACGTATGGGAA
CCAAGGCGCCAGCCGTGGCGCGCCTGGAAAGTTCATTAGCTTCGGGTAAGCACTCTCCTAGCATCAATACATTACGCAAA
TATGCGGCAGCGCTTGGAAAACGCCTCGAAGTGCATCTGGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A127R352