Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-timR/SymE(toxin)
Location 4339080..4339492 Replicon chromosome
Accession NZ_CP103589
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag M5T00_RS21065 Protein ID WP_000132614.1
Coordinates 4339151..4339492 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name timR
Locus tag -
Coordinates 4339080..4339156 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS21055 (4335692) 4335692..4337161 + 1470 WP_001387312.1 type I restriction-modification system subunit M -
M5T00_RS21060 (4337161) 4337161..4338930 + 1770 WP_001513535.1 restriction endonuclease subunit S -
- (4339080) 4339080..4339156 - 77 NuclAT_8 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_8 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_8 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_8 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_9 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_9 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_9 - Antitoxin
- (4339080) 4339080..4339156 - 77 NuclAT_9 - Antitoxin
M5T00_RS21065 (4339151) 4339151..4339492 + 342 WP_000132614.1 endoribonuclease SymE Toxin
M5T00_RS21070 (4339539) 4339539..4340702 - 1164 WP_224153787.1 DUF1524 domain-containing protein -
M5T00_RS21075 (4340756) 4340756..4341632 - 877 Protein_4127 DUF262 domain-containing protein -
M5T00_RS21080 (4342038) 4342038..4342958 - 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
M5T00_RS21085 (4343143) 4343143..4344423 + 1281 WP_001338077.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4323468..4339492 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T255709 WP_000132614.1 NZ_CP103589:4339151-4339492 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT255709 NZ_CP103589:c4339156-4339080 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References