Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4259387..4259645 Replicon chromosome
Accession NZ_CP103589
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag M5T00_RS20670 Protein ID WP_000809168.1
Coordinates 4259493..4259645 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4259387..4259444 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS20655 4255216..4256475 - 1260 WP_000494929.1 hypothetical protein -
M5T00_RS20660 4256604..4258097 - 1494 WP_115786610.1 sulfatase-like hydrolase/transferase -
M5T00_RS20665 4258117..4258878 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4259387..4259444 - 58 - - Antitoxin
M5T00_RS20670 4259493..4259645 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
M5T00_RS20675 4259750..4260880 - 1131 WP_001118464.1 molecular chaperone DnaJ -
M5T00_RS20680 4260969..4262885 - 1917 WP_000516135.1 molecular chaperone DnaK -
M5T00_RS20685 4263257..4263661 + 405 WP_000843687.1 DUF2541 family protein -
M5T00_RS20690 4263687..4264400 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T255708 WP_000809168.1 NZ_CP103589:4259493-4259645 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT255708 NZ_CP103589:c4259444-4259387 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References