Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3788167..3788771 Replicon chromosome
Accession NC_015856
Organism Collimonas fungivorans Ter331

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFU_RS16720 Protein ID WP_041743607.1
Coordinates 3788460..3788771 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFU_RS16715 Protein ID WP_014007215.1
Coordinates 3788167..3788457 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU_RS16690 3783857..3784171 + 315 WP_014007210.1 pyrimidine/purine nucleoside phosphorylase -
CFU_RS16695 3784325..3785356 - 1032 WP_014007211.1 UDP-N-acetylmuramate dehydrogenase -
CFU_RS16700 3785507..3785992 + 486 WP_014007212.1 YajQ family cyclic di-GMP-binding protein -
CFU_RS16705 3786096..3786731 + 636 WP_041742233.1 TIGR02281 family clan AA aspartic protease -
CFU_RS16710 3786786..3787853 - 1068 WP_041742234.1 3-deoxy-7-phosphoheptulonate synthase AroG -
CFU_RS16715 3788167..3788457 - 291 WP_014007215.1 helix-turn-helix domain-containing protein Antitoxin
CFU_RS16720 3788460..3788771 - 312 WP_041743607.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFU_RS16725 3789017..3790222 - 1206 WP_014007217.1 MFS transporter -
CFU_RS16730 3790545..3791108 + 564 WP_014007218.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
CFU_RS16735 3791105..3791848 + 744 WP_014007219.1 2OG-Fe(II) oxygenase -
CFU_RS16740 3791859..3792521 + 663 WP_041742235.1 DNA oxidative demethylase AlkB -
CFU_RS16745 3792534..3793217 + 684 WP_041742236.1 DNA-3-methyladenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-75)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11962.88 Da        Isoelectric Point: 9.2617

>T25570 WP_041743607.1 NC_015856:c3788771-3788460 [Collimonas fungivorans Ter331]
MEFIETPTFTRMITALLAEEEYRELQSVLMEDPSRGDVIKDGGGIRKMRYAARGRGKSGGIRVIYYWIKDNHQVYMLVAY
PKSKKDTLSDKEIAILREFVKEL

Download         Length: 312 bp

>T25570 NC_015856:c3788771-3788460 [Collimonas fungivorans Ter331]
ATGGAATTCATCGAGACGCCCACTTTTACTCGGATGATCACAGCCTTGCTTGCAGAGGAAGAATACCGGGAACTGCAATC
GGTATTGATGGAGGATCCGTCCCGGGGCGATGTCATCAAAGATGGCGGCGGCATCCGCAAAATGCGGTACGCAGCGCGAG
GTCGTGGCAAAAGCGGCGGAATCAGAGTGATCTATTATTGGATAAAGGATAACCACCAGGTTTACATGCTAGTGGCCTAT
CCGAAATCCAAAAAAGATACGCTATCCGATAAGGAAATTGCTATTTTGCGGGAATTTGTGAAGGAACTGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10647.27 Da        Isoelectric Point: 10.3121

>AT25570 WP_014007215.1 NC_015856:c3788457-3788167 [Collimonas fungivorans Ter331]
MENVLFDDLLQSLKEAKAISEGKAEASRRFQMSPTDVKAVREQIGLSQSEFAKLMRVSIKTLQNWEQHRRSPTGPAAALL
KIVSTAPDIALKSLHS

Download         Length: 291 bp

>AT25570 NC_015856:c3788457-3788167 [Collimonas fungivorans Ter331]
ATGGAAAATGTACTTTTTGATGACCTGCTGCAAAGTCTGAAAGAAGCAAAGGCTATTTCCGAAGGGAAAGCCGAGGCATC
GCGCCGATTTCAGATGTCGCCTACCGATGTAAAAGCCGTTCGTGAGCAAATTGGCTTATCTCAGAGCGAATTTGCAAAAC
TGATGCGTGTCAGCATCAAGACTTTGCAAAACTGGGAGCAGCACCGGCGCAGTCCGACTGGCCCAGCCGCCGCCTTGCTC
AAAATTGTATCAACGGCGCCAGATATAGCGCTTAAGTCATTGCATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References