Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1959243..1959745 Replicon chromosome
Accession NZ_CP103589
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag M5T00_RS09395 Protein ID WP_000767822.1
Coordinates 1959491..1959745 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5T00_RS09390 Protein ID WP_001259255.1
Coordinates 1959243..1959494 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS09365 (1954421) 1954421..1955488 - 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5T00_RS09370 (1955488) 1955488..1956558 - 1071 WP_001538918.1 histidinol-phosphate transaminase -
M5T00_RS09375 (1956555) 1956555..1957859 - 1305 WP_001445483.1 histidinol dehydrogenase -
M5T00_RS09380 (1957865) 1957865..1958764 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
M5T00_RS09385 (1958910) 1958910..1958960 - 51 WP_001364200.1 his operon leader peptide -
M5T00_RS09390 (1959243) 1959243..1959494 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5T00_RS09395 (1959491) 1959491..1959745 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5T00_RS09400 (1959828) 1959828..1960652 + 825 WP_000754737.1 SDR family oxidoreductase -
M5T00_RS09405 (1960698) 1960698..1961627 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M5T00_RS09410 (1961842) 1961842..1961904 + 63 WP_010723108.1 membrane protein YoeI -
M5T00_RS09415 (1961894) 1961894..1963252 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T255698 WP_000767822.1 NZ_CP103589:1959491-1959745 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255698 WP_001259255.1 NZ_CP103589:1959243-1959494 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References