Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2417929..2418618 Replicon chromosome
Accession NZ_CP103586
Organism Klebsiella pneumoniae strain 4737

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag M5T07_RS11955 Protein ID WP_021469727.1
Coordinates 2417929..2418246 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag M5T07_RS11960 Protein ID WP_020804705.1
Coordinates 2418322..2418618 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T07_RS11925 (2413631) 2413631..2414140 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
M5T07_RS11930 (2414150) 2414150..2415076 + 927 WP_032435210.1 amino acid ABC transporter permease -
M5T07_RS11935 (2415060) 2415060..2415839 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
M5T07_RS11940 (2415878) 2415878..2416729 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
M5T07_RS11945 (2416807) 2416807..2417424 + 618 WP_032425015.1 glutathione S-transferase family protein -
M5T07_RS11950 (2417495) 2417495..2417722 + 228 WP_002906690.1 tautomerase PptA -
M5T07_RS11955 (2417929) 2417929..2418246 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T07_RS11960 (2418322) 2418322..2418618 + 297 WP_020804705.1 NadS family protein Antitoxin
M5T07_RS11965 (2418697) 2418697..2419143 + 447 WP_032435212.1 hypothetical protein -
M5T07_RS11970 (2419184) 2419184..2420800 - 1617 WP_004175961.1 carbohydrate porin -
M5T07_RS11975 (2420844) 2420844..2422226 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T255684 WP_021469727.1 NZ_CP103586:2417929-2418246 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT255684 WP_020804705.1 NZ_CP103586:2418322-2418618 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References