Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352874..353520 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag M5S97_RS01635 Protein ID WP_016529833.1
Coordinates 352874..353221 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S97_RS01640 Protein ID WP_141408257.1
Coordinates 353221..353520 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS01625 (M5S97_01625) 348800..350233 + 1434 WP_002920564.1 glycogen synthase GlgA -
M5S97_RS01630 (M5S97_01630) 350251..352698 + 2448 WP_002920561.1 glycogen phosphorylase -
M5S97_RS01635 (M5S97_01635) 352874..353221 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S97_RS01640 (M5S97_01640) 353221..353520 + 300 WP_141408257.1 XRE family transcriptional regulator Antitoxin
M5S97_RS01645 (M5S97_01645) 353583..355091 - 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
M5S97_RS01650 (M5S97_01650) 355296..355625 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M5S97_RS01655 (M5S97_01655) 355676..356506 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M5S97_RS01660 (M5S97_01660) 356556..357314 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T255660 WP_016529833.1 NZ_CP103582:352874-353221 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10761.50 Da        Isoelectric Point: 9.7681

>AT255660 WP_141408257.1 NZ_CP103582:353221-353520 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References