Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 326686..327272 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag M5S97_RS01525 Protein ID WP_023285605.1
Coordinates 326904..327272 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag M5S97_RS01520 Protein ID WP_004174006.1
Coordinates 326686..326907 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS01500 (M5S97_01500) 322843..323769 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
M5S97_RS01505 (M5S97_01505) 323766..325043 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
M5S97_RS01510 (M5S97_01510) 325040..325807 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
M5S97_RS01515 (M5S97_01515) 325809..326522 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
M5S97_RS01520 (M5S97_01520) 326686..326907 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5S97_RS01525 (M5S97_01525) 326904..327272 + 369 WP_023285605.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M5S97_RS01530 (M5S97_01530) 327545..328861 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
M5S97_RS01535 (M5S97_01535) 328968..329855 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
M5S97_RS01540 (M5S97_01540) 329852..330697 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
M5S97_RS01545 (M5S97_01545) 330699..331769 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 323766..332506 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13534.89 Da        Isoelectric Point: 8.6410

>T255659 WP_023285605.1 NZ_CP103582:326904-327272 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGITVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT255659 WP_004174006.1 NZ_CP103582:326686-326907 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References