Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 751066..751841 Replicon chromosome
Accession NZ_CP103579
Organism Klebsiella pneumoniae strain 4014

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag M5S61_RS03765 Protein ID WP_060568463.1
Coordinates 751356..751841 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M5S61_RS03760 Protein ID WP_004150912.1
Coordinates 751066..751359 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S61_RS03740 (746274) 746274..746876 - 603 WP_004174410.1 short chain dehydrogenase -
M5S61_RS03745 (746974) 746974..747885 + 912 WP_023342207.1 LysR family transcriptional regulator -
M5S61_RS03750 (747886) 747886..749034 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
M5S61_RS03755 (749045) 749045..750421 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
M5S61_RS03760 (751066) 751066..751359 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M5S61_RS03765 (751356) 751356..751841 + 486 WP_060568463.1 GNAT family N-acetyltransferase Toxin
M5S61_RS03770 (752545) 752545..753138 + 594 WP_004188553.1 hypothetical protein -
M5S61_RS03775 (753235) 753235..753451 + 217 Protein_741 transposase -
M5S61_RS03785 (754292) 754292..755005 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 753235..753387 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17602.64 Da        Isoelectric Point: 8.1629

>T255646 WP_060568463.1 NZ_CP103579:751356-751841 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRHNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT255646 WP_004150912.1 NZ_CP103579:751066-751359 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References