Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1106481..1107156 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag M5S64_RS05355 Protein ID WP_015571638.1
Coordinates 1106857..1107156 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag M5S64_RS05350 Protein ID WP_015571639.1
Coordinates 1106481..1106846 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS05330 (M5S64_05330) 1102937..1103668 + 732 WP_017382760.1 methyltransferase domain-containing protein -
M5S64_RS05335 (M5S64_05335) 1103665..1104267 - 603 WP_045340137.1 short chain dehydrogenase -
M5S64_RS05340 (M5S64_05340) 1104365..1105252 + 888 WP_015571641.1 LysR family transcriptional regulator -
M5S64_RS05345 (M5S64_05345) 1105273..1106454 + 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
M5S64_RS05350 (M5S64_05350) 1106481..1106846 - 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
M5S64_RS05355 (M5S64_05355) 1106857..1107156 - 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S64_RS05360 (M5S64_05360) 1107407..1108606 - 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
M5S64_RS05365 (M5S64_05365) 1108587..1110779 - 2193 WP_017692801.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T255633 WP_015571638.1 NZ_CP103577:c1107156-1106857 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT255633 WP_015571639.1 NZ_CP103577:c1106846-1106481 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References