Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3630673..3631214 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag M5S79_RS17510 Protein ID WP_000615983.1
Coordinates 3630936..3631214 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag M5S79_RS17505 Protein ID WP_000729703.1
Coordinates 3630673..3630933 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS17485 (3626348) 3626348..3627133 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
M5S79_RS17490 (3627105) 3627105..3628817 + 1713 Protein_3420 flagellar biosynthesis protein FlhA -
M5S79_RS17495 (3629041) 3629041..3629538 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
M5S79_RS17500 (3629714) 3629714..3630463 - 750 WP_000056849.1 C40 family peptidase -
M5S79_RS17505 (3630673) 3630673..3630933 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
M5S79_RS17510 (3630936) 3630936..3631214 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
M5S79_RS17515 (3631370) 3631370..3632110 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
M5S79_RS17520 (3632081) 3632081..3632848 - 768 WP_000333380.1 class II glutamine amidotransferase -
M5S79_RS17525 (3633054) 3633054..3633632 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3624476..3639756 15280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T255620 WP_000615983.1 NZ_CP103570:3630936-3631214 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT255620 WP_000729703.1 NZ_CP103570:3630673-3630933 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References