Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5001669..5002271 Replicon chromosome
Accession NZ_CP103562
Organism Escherichia coli O25b:H4-ST131 strain 751

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag M5R24_RS24590 Protein ID WP_000897302.1
Coordinates 5001960..5002271 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5R24_RS24585 Protein ID WP_000356397.1
Coordinates 5001669..5001959 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R24_RS24555 (4996976) 4996976..4997905 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
M5R24_RS24560 (4998087) 4998087..4998329 - 243 WP_001068514.1 CopG family transcriptional regulator -
M5R24_RS24565 (4998619) 4998619..4999467 + 849 WP_001038650.1 hypothetical protein -
M5R24_RS24570 (4999492) 4999492..5000232 + 741 WP_000608806.1 hypothetical protein -
M5R24_RS24575 (5000417) 5000417..5000635 - 219 WP_001251293.1 CopG family transcriptional regulator -
M5R24_RS24580 (5001032) 5001032..5001310 - 279 WP_001296612.1 hypothetical protein -
M5R24_RS24585 (5001669) 5001669..5001959 - 291 WP_000356397.1 NadS family protein Antitoxin
M5R24_RS24590 (5001960) 5001960..5002271 - 312 WP_000897302.1 hypothetical protein Toxin
M5R24_RS24595 (5002500) 5002500..5003408 + 909 WP_001385591.1 alpha/beta hydrolase -
M5R24_RS24600 (5003472) 5003472..5004413 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5R24_RS24605 (5004458) 5004458..5004895 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
M5R24_RS24610 (5004892) 5004892..5005764 - 873 WP_000920762.1 virulence factor BrkB family protein -
M5R24_RS24615 (5005758) 5005758..5006357 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T255578 WP_000897302.1 NZ_CP103562:c5002271-5001960 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT255578 WP_000356397.1 NZ_CP103562:c5001959-5001669 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References