Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 3607580..3608250 | Replicon | chromosome |
| Accession | NC_015848 | ||
| Organism | Mycobacterium canettii CIPT 140010059 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | G0THF5 |
| Locus tag | MCAN_RS16825 | Protein ID | WP_014001612.1 |
| Coordinates | 3607580..3607924 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0THF6 |
| Locus tag | MCAN_RS16830 | Protein ID | WP_003899955.1 |
| Coordinates | 3607921..3608250 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCAN_RS16795 | 3602653..3603513 | + | 861 | WP_014001610.1 | alpha/beta hydrolase | - |
| MCAN_RS16800 | 3603488..3604003 | + | 516 | WP_015288470.1 | nitroreductase family deazaflavin-dependent oxidoreductase | - |
| MCAN_RS16805 | 3604243..3604536 | + | 294 | WP_003416635.1 | hypothetical protein | - |
| MCAN_RS16810 | 3604824..3606113 | + | 1290 | WP_003416640.1 | ATP-binding protein | - |
| MCAN_RS16815 | 3606460..3606894 | - | 435 | WP_003899952.1 | type II toxin-antitoxin system VapC family toxin | - |
| MCAN_RS16820 | 3606897..3607349 | - | 453 | WP_003899953.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MCAN_RS16825 | 3607580..3607924 | + | 345 | WP_014001612.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MCAN_RS16830 | 3607921..3608250 | + | 330 | WP_003899955.1 | XRE family transcriptional regulator | Antitoxin |
| MCAN_RS16835 | 3608788..3609135 | + | 348 | WP_003899956.1 | DUF2384 domain-containing protein | - |
| MCAN_RS16840 | 3609132..3609755 | + | 624 | WP_014001613.1 | RES domain-containing protein | - |
| MCAN_RS16850 | 3609878..3611139 | + | 1262 | WP_145974184.1 | IS3-like element IS987 family transposase | - |
| MCAN_RS16855 | 3611186..3611959 | + | 774 | WP_014001615.1 | hypothetical protein | - |
| MCAN_RS16860 | 3611986..3613020 | - | 1035 | WP_014001616.1 | IS30 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12752.60 Da Isoelectric Point: 5.6920
>T25554 WP_014001612.1 NC_015848:3607580-3607924 [Mycobacterium canettii CIPT 140010059]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRFENWLASEHGGG
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRFENWLASEHGGG
Download Length: 345 bp
>T25554 NC_015848:3607580-3607924 [Mycobacterium canettii CIPT 140010059]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTTCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTTCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
Antitoxin
Download Length: 110 a.a. Molecular weight: 11802.46 Da Isoelectric Point: 7.4051
>AT25554 WP_003899955.1 NC_015848:3607921-3608250 [Mycobacterium canettii CIPT 140010059]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
Download Length: 330 bp
>AT25554 NC_015848:3607921-3608250 [Mycobacterium canettii CIPT 140010059]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACCGTCGAGCT
GACCGCCTGA
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACCGTCGAGCT
GACCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|