Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1893519..1894021 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag M5T18_RS08930 Protein ID WP_000767820.1
Coordinates 1893767..1894021 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5T18_RS08925 Protein ID WP_001259255.1
Coordinates 1893519..1893770 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS08900 (1888696) 1888696..1889763 - 1068 WP_001403692.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5T18_RS08905 (1889763) 1889763..1890833 - 1071 WP_001403691.1 histidinol-phosphate transaminase -
M5T18_RS08910 (1890830) 1890830..1892134 - 1305 WP_001403690.1 histidinol dehydrogenase -
M5T18_RS08915 (1892140) 1892140..1893039 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5T18_RS08920 (1893185) 1893185..1893235 - 51 WP_001364200.1 his operon leader peptide -
M5T18_RS08925 (1893519) 1893519..1893770 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5T18_RS08930 (1893767) 1893767..1894021 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5T18_RS08935 (1894104) 1894104..1894928 + 825 WP_000754749.1 SDR family oxidoreductase -
M5T18_RS08940 (1894974) 1894974..1895903 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
M5T18_RS08945 (1896118) 1896118..1896180 + 63 WP_010723108.1 membrane protein YoeI -
M5T18_RS08950 (1896170) 1896170..1897528 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
M5T18_RS08955 (1897707) 1897707..1898765 + 1059 WP_000492315.1 thiosulfate utilization transporter TsuA/YeeE -
M5T18_RS08960 (1898779) 1898779..1899006 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T255515 WP_000767820.1 NZ_CP103559:1893767-1894021 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255515 WP_001259255.1 NZ_CP103559:1893519-1893770 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References