Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 622128..622927 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag M5T18_RS03015 Protein ID WP_000347270.1
Coordinates 622128..622592 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag M5T18_RS03020 Protein ID WP_001551693.1
Coordinates 622592..622927 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS02985 (617129) 617129..617563 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M5T18_RS02990 (617581) 617581..618459 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M5T18_RS02995 (618449) 618449..619228 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M5T18_RS03000 (619239) 619239..619712 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M5T18_RS03005 (619735) 619735..621015 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
M5T18_RS03010 (621264) 621264..622073 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M5T18_RS03015 (622128) 622128..622592 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M5T18_RS03020 (622592) 622592..622927 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M5T18_RS03025 (623076) 623076..624647 - 1572 WP_001273738.1 galactarate dehydratase -
M5T18_RS03030 (625022) 625022..626356 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
M5T18_RS03035 (626372) 626372..627142 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T255510 WP_000347270.1 NZ_CP103559:c622592-622128 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT255510 WP_001551693.1 NZ_CP103559:c622927-622592 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References